实用老年医学

实用老年医学 ›› 2025, Vol. 39 ›› Issue (5): 492-496.doi: 10.3969/j.issn.1003-9198.2025.05.012

• 临床研究 • 上一篇    下一篇

血清PGC-1α、Omentin-1对老年股骨粗隆间骨折病人术后髋关节功能不良的预测价值

林朋朝, 李静, 白佳悦, 高伟静, 葛瑞红, 路慧青, 王文娟, 郝康宁, 王江泳, 周晓彬, 冯建书   

  1. 050011 河北省石家庄市,石家庄市第三医院创伤三科(林朋朝,白佳悦,高伟静,葛瑞红,郝康宁,王江泳,周晓彬,冯建书);心胸外科(路慧青);创伤一科(王文娟); 050022 河北省石家庄市,河北省第八人民医院护理部(李静)
  • 收稿日期:2024-07-22 出版日期:2025-05-20 发布日期:2025-05-20
  • 基金资助:
    河北省卫健委医学科学研究课题计划(20210547)

Predictive value of serum PGC-1α and Omentin-1 for postoperative hip joint dysfunction in elderly patients with intertrochanteric fractures of the femur

LIN Pengchao, LI Jing, BAI Jiayue, GAO Weijing, GE Ruihong, LU Huiqing, WANG Wenjuan, HAO Kangning, WANG Jiangyong, ZHOU Xiaobin, FENG Jianshu   

  1. The Third Trauma Department(LIN Pengchao,BAI Jiayue,GAO Weijing,GE Ruihong,HAO Kangning,WANG Jiangyong, ZHOU Xiaobin, FENG Jianshu);Department of Cardiothoracic Surgery(LU Huiqing); the First Trauma Department (WANG Wenjuan), Shijiazhuang Third Hospital, Shijiazhuang 050011,China; Nursing Department,the Eighth People’s Hospital of Hebei Province, Shijiazhuang 050022, China(LI Jing)
  • Received:2024-07-22 Online:2025-05-20 Published:2025-05-20

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摘要： 目的 分析血清过氧化物酶体增殖物激活受体γ共激活因子-1α(PGC-1α)、网膜素1(Omentin-1)对老年股骨粗隆间骨折(IFF)病人术后髋关节功能不良的预测价值。 方法 选取2017年6月至2023年6月在石家庄市第三医院行骨科手术的114例老年IFF病人,术后随访8个月,根据髋关节功能情况将病人分为不良组(30例)和良好组(84例)。采用ELISA法检测病人血清PGC-1α、Omentin-1水平。采用多元logistic回归(逐步向前法)分析老年IFF病人术后髋关节功能不良的影响因素。绘制血清PGC-1α、Omentin-1预测老年IFF病人术后髋关节功能不良的ROC曲线,并计算AUC。 结果 不良组病人血清PGC-1α、Omentin-1水平显著低于良好组(P<0.01)。2组年龄、术前AO分型差异有统计学意义(P<0.05)。多元logistic回归分析显示,术前AO分型、PGC-1α、Omentin-1是老年IFF病人术后髋关节功能不良的独立影响因素。血清PGC-1α、Omentin-1联合预测老年IFF病人术后髋关节功能不良的AUC为0.942(95%CI:0.899~0.984),显著优于PGC-1α(AUC=0.825,Z=2.468,P=0.014)、Omentin-1(AUC=0.819,Z=2.500,P=0.012)单独预测。 结论 血清PGC-1α、Omentin-1在老年IFF术后髋关节功能不良的病人中水平下调,二者联合对髋关节功能不良具有较好的预测价值,可为临床预后预测提供参考。

关键词: 股骨粗隆间骨折, 髋关节功能, 过氧化物酶体增殖物激活受体γ共激活因子-1α, 网膜素1

Abstract: Objective To analyze the predictive value of serum levels of peroxisome proliferator activated receptor gamma coactivator-1α (PGC-1α) and Omentin-1 for postoperative hip joint dysfunction in the elderly patients with intertrochanteric fractures of the femur (IFF). Methods A total of 114 elderly patients with IFF who underwent surgical treatment in the Orthopedics Department of Shijiazhuang Third Hospital from June 2017 to June 2023 were enrolled in this study. Based on an 8-month follow-up after surgery, the patients were divided into poor prognosis group (30 cases) and good prognosis group (84 cases). The serum levels of PGC-1α and Omentin-1 were measured by enzyme linked immunosorbent assay. Multiple logistic regression (step forward method) was applied to analyze the influencing factors of postoperative hip joint dysfunction in the elderly patients with IFF. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of PGC-1α and Omentin-1 for postoperative hip joint dysfunction in the elderly patients with IFF, and the area under the curve (AUC) was calculated. Results The serum levels of PGC-1α and Omentin-1 in poor prognosis group were significantly lower than those in good prognosis group (P<0.01). There were significant differences in age, preoperative AO classification between the two groups (P<0.05). Multivariable logistic regression analysis showed that preoperative AO classification,the levels of PGC-1α and Omentin-1 were independent influencing factors for postoperative hip joint dysfunction in the elderly patients with IFF. The AUC of serum PGC-1α combined with Omentin-1 in predicting postoperative hip joint dysfunction was 0.942 (95%CI: 0.899-0.984), which was superior to those of PGC-1α alone(AUC=0.825, Z=2.468, P=0.014) and Omentin-1 alone (AUC=0.819, Z=2.500, P=0.012). Conclusions Serum levels of PGC-1α and Omentin-1 are down-regulated in the elderly IFF patients with postoperative hip joint dysfunction. The combination of the two indicators can improve the predictive value for hip joint dysfunction and provide clinical reference for prognosis.

Key words: intertrochanteric fracture of the femur, hip joint function, peroxisome proliferator-activated receptor gamma coactivator-1, Omentin-1

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