肠道微生物及其代谢产物与中枢神经自身免疫性疾病关系的研究进展

doi:10.3969/j.issn.1003-9198.2024.08.022

摘要/Abstract

摘要： 中枢神经系统(central nervous system, CNS)自身免疫性疾病是一类由机体免疫功能异常引发CNS功能障碍的疾病,其种类繁杂,具有高致残性,目前临床上针对此类疾病尚无有效治疗措施。近年来,肠道微生物群作为人体胃肠道与大脑的沟通桥梁,已被证明和神经系统、免疫系统等多系统疾病的发生发展密切相关。本文通过综述近年关于肠道微生物及其代谢产物与CNS自身免疫性疾病间相互影响的文献,并讨论调节肠道微生物群在CNS自身免疫性疾病防治中的作用,旨在从微生态学角度阐释靶向肠道微生物群相关诊治的机制并论证其有效性,以期为CNS自身免疫性疾病的临床诊治寻找新的潜在靶点。

关键词: 肠道微生物, 中枢神经系统, 自身免疫性疾病, 微生物群代谢产物

中图分类号:

R593

范诗宇, 张军风, 闫隆, 于涛. 肠道微生物及其代谢产物与中枢神经自身免疫性疾病关系的研究进展[J]. 实用老年医学, 2024, 38(8): 851-856.

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