老年人肌肉功能与认知功能的相关性研究

doi:10.3969/j.issn.1003-9198.2022.04.015

摘要/Abstract

摘要： 目的探讨老年人肌肉功能与认知功能的相关性。方法连续入选宣武医院老年医学科老年病人385例,采集临床和实验室资料,并进行肌肉功能及认知功能检查,根据是否合并认知功能障碍分为认知功能障碍组(n=32)和无认知功能障碍组(n=353),分析肌肉功能与认知功能的相关性。结果认知功能障碍组的年龄、起立行走试验时间均明显高于无认知功能障碍组;4 m步速、上臂围、小腿围、握力、TG、Hb水平、MMSE总分均明显低于无认知功能障碍组,差异有统计学意义(P＜0.05)。而2组的性别、四肢骨骼肌质量(ASM)、四肢骨骼肌指数(ASMI)及合并高血压、T2DM、冠心病等比较,差异均无统计学意义。Spearman相关性分析显示,控制年龄变量后,认知功能与握力(r=0.145, P=0.005)、4 m步速(r=0.126, P=0.018)呈正相关。二分类Logistic回归分析显示:握力为认知功能障碍的独立危险因素(OR=1.099,95％CI:1.016~1.188,P=0.019)。结论肌肉功能下降会明显降低老年人认知功能,两者具有相关性,握力为认知功能障碍的危险因素。

关键词: 肌肉功能, 握力, 步速, 认知功能

Abstract: Objective To investigate the correlation between muscle function and cognitive function in the elderly. Methods A total of 385 elderly patients admitted to Department of Geriatrics in Xuanwu Hospital were selected consecutively. The clinical and laboratory examination data, muscle function and cognitive function were evaluated and collected. The patients were divided into cognitive dysfunction group(n=32) and non-cognitive dysfunction group(n=353) according to the score of Mini-Mental State Examination(MMSE).The correlation between muscle function and cognitive function in the elderly people were analyzed. Results Age, “get-up and go” test time were significantly higher, and four meters step speed, upper arm circumference, lower leg circumference, grip strength, the levels of triylyceride, hemoglobin and MMSE score were significantly lower in the cognitive dysfunction group than those in the non-cognitive dysfunction group(P<0.05). Whereas gender, appendicular skeletal muscle mass(ASM), appendicular skeletal muscle mass index(ASMI), the incidence of hypertension, type 2 diabetes mellitus, coronary heart disease showed no significantly difference between the two groups(P> 0.05). Spearman correlation analysis showed that after controlling for age variables, cognitive function was positively related with grip strength(r=0.145, P=0.005) and four meters step speed(r=0.126, P=0.018). Logistic regression analysis revealed that grip strength was a risk factor for cognitive dysfunction(OR=1.099,95％CI:1.016-1.188,P=0.019). Conclusions Decreased muscle function significantly reduced cognitive function in the elderly. Cognitive function is positively related with muscle function. Grip strength was a risk factor for cognitive dysfunction.

Key words: muscle function, grip strength, step speed, cognitive function

中图分类号:

R 749.16

李碧汐, 张亚欣, 刘盼, 宋雨, 李耘, 马丽娜. 老年人肌肉功能与认知功能的相关性研究[J]. 实用老年医学, 2022, 36(4): 386-389.

LI Bi-xi, ZHANG Ya-xin, LIU Pan, SONG Yu, LI Yun, MA Li-na. Correlation between muscle function and cognitive function in elderly[J]. Practical Geriatrics, 2022, 36(4): 386-389.

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