肠菌移植在肌少症中的研究进展

doi:10.3969/j.issn.1003-9198.2026.09.017

摘要/Abstract

摘要： 肌少症是老龄化社会面临的重大健康挑战,目前缺乏有效的干预措施。肠菌移植作为重建肠道微生态的核心手段,近年来在肌少症领域取得突破性进展。现有证据已初步确立肠道菌群失调与肌少症之间的因果关系,肠菌移植在动物模型中效果明确,近期临床研究亦显示阳性结果。本综述系统阐述肠菌移植干预肌少症的临床前与临床证据及其作用机制,基于现有证据,我们认为肠菌移植可通过调控菌群代谢物、修复肠道屏障、抑制慢性炎症、改善线粒体功能等多靶点改善骨骼肌质量与功能。随着关键功能菌株的不断鉴定,肠菌移植有望迈向精准化、标准化的靶向干预,成为肌少症防治的新型治疗策略。

关键词: 肌少症, 肠菌移植, 肠道菌群, 肠-肌轴, 作用机制

Abstract: Sarcopenia represents a major health challenge in aging societies, yet effective interventions remain limited. As a core approach for gut microbiota reconstruction, fecal microbiota transplantation (FMT) has achieved groundbreaking progress in sarcopenia in recent years. Current evidence has preliminarily established a causal relationship between gut dysbiosis and sarcopenia. FMT has shown clear efficacy in animal models, and recent clinical studies have also reported positive results. This review systematically summarizes the preclinical and clinical evidence of FMT in sarcopenia, along with its underlying mechanisms. Based on the available evidence, we propose that FMT can improve skeletal muscle mass and function through multiple targets, including the regulation of microbial metabolites, restoration of the intestinal barrier, suppression of chronic inflammation, and enhancement of mitochondrial function. As key functional bacterial strains continue to be identified, FMT is expected to evolve into a precise, standardized targeted intervention, emerging as a novel therapeutic strategy for the prevention and treatment of sarcopenia.

Key words: sarcopenia, fecal microbiota transplantation, gut microbiota, gut-muscle axis, mechanism

中图分类号:

R 592
R 685

李佳欢, 乐岭, 吴全新, 傅涛. 肠菌移植在肌少症中的研究进展[J]. 实用老年医学, 2026, 40(9): 952-956.

LI Jiahuan, YUE Ling, WU Quanxin, FU Tao. Research progress of fecal microbiota transplantation in sarcopenia[J]. Practical Geriatrics, 2026, 40(9): 952-956.

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