多酚基于微生物-肠-脑轴在神经退行性疾病中的研究进展

doi:10.3969/j.issn.1003-9198.2025.10.018

摘要/Abstract

摘要： 我国人口老龄化问题日益严峻,神经退行性疾病(neurodegenerative diseases,NDs)目前仍缺乏科学有效的治疗措施。近年来,肠道微生物群被认为在许多神经系统疾病中发挥作用,通过改变饮食结构等方法可以改善其组成,从而对NDs产生积极的影响。有证据表明,多酚抗炎抗氧化的特性可以通过微生物-肠-脑轴调节中枢神经系统(CNS)的活动,这为NDs的治疗提供了新的视角。本文综述多酚通过微生物-肠-脑轴系统对NDs的保护作用及其机制,以期为NDs的临床治疗提供可能的策略。

关键词: 多酚, 微生物物群, 肠-脑轴, 神经退行性疾病, 抗氧化剂, 抗炎效应

Abstract: The aging population presents a growing challenge, while neurodegenerative diseases (NDs) still lack scientifically validated treatments. Recent studies have highlighted the gut microbiota’s role in neurological disorders, suggesting dietary modifications could optimize its composition to positively influence NDs. Evidence demonstrates that polyphenols’ anti-inflammatory and antioxidant properties may modulate central nervous system (CNS) activity through the microbiota-gut-brain axis, offering novel therapeutic approaches. This review reveals polyphenols’ protective mechanisms via this axis in NDs, identifying potential clinical strategies for managing these conditions.

Key words: polyphenols, microbiota, gut-brain axis, neurodegenerative diseases, antioxidants, anti-inflammatory effects

中图分类号:

R 741

徐洁, 王妍, 顾小萍. 多酚基于微生物-肠-脑轴在神经退行性疾病中的研究进展[J]. 实用老年医学, 2025, 39(10): 1057-1061.

XU Jie, WANG Yan, GU Xiaoping. Advances of polyphenols based on the microbial-gut-brain axis in neurodegenerative diseases[J]. Practical Geriatrics, 2025, 39(10): 1057-1061.

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