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Analysis of influencing factors of chemotherapy tolerance in elderly patients with colorectal cancer
DENG Shi-chao, SHEN Hao, SUN Qiang, CHEN Jia-dong, MA Bao-jin
2023, 37 (5):
500-504.
doi: 10.3969/j.issn.1003-9198.2023.05.016
Objective To explore the influencing factors of chemotherapy tolerance in the elderly patients with colorectal cancer, in order to provide basis for screening elderly patients suitable for chemotherapy. Methods A retrospective study was conducted among 154 elderly patients(aged ≥65 years) who were diagnosed as colorectal cancer and received chemotherapy from 2017 to 2021, and the patients were divided into good chemotherapy tolerance group, basic chemotherapy tolerance group, and chemotherapy intolerance group according to the chemotherapy outcomes. The basic conditions, tumor conditions, nutritional status, emotional conditions and treatment conditions were compared in the three groups. Multivariate regression analysis was further performed to analyze the independent risk factors of chemotherapy tolerance in the elderly patients with colorectal cancer. Results Among 154 patients, 108 presented with good chemotherapy tolerance, 27 with basic chemotherapy tolerance (70.2%) and 19 with chemotherapy intolerance. Single factor analysis showed that age, number of basic diseases, tumor site, clinical stage, treatment mode, Performance Status(PS)Score, nutritional status, depression, and the levels of platelet, hemoglobin(Hb), prealbumin, albumin and carcinoembryonic antigen(CEA) were significantly different among the groups. Logistic regression analysis showed that tumor site, clinical stage, treatment mode, PS score, nutritional status, depression, Hb, albumin, and CEA were the independent influcencing factors for poor chemotherapy tolerance. Conclusions Elderly patients with colorectal cancer should receive active anti-cancer treatment. Chemotherapy as the main anti-cancer treatment should not be judged simply by age. Hb, albumin and CEA can be used as predictive indicators for prognosis. At the same time, tumor site, clinical stage, treatment mode, PS score, nutritional status and depression should also be considered as the independent influencing factors.
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