Abstract:

ＯｂｊｅｃｔｉｖｅTo discuss the relationships of the level of urinary 11dehydrothromboxane B2 (11DHTXB2) with cognitive function in elderly senior intellectuals with asymptomatic cerebral infarction.ＭｅｔｈｏｄｓSixty patients (40 men, 20 women) with a mean age of 722±61 years, participated in this study and definitely suffered from asymptomatic cerebral infarction confirmed by brain MRI. Their education were all higher than the university levels (including university). Urinary 11DHTXB2 level was detected by enzyme linked immunosorbent assay. MMSE and MOCA were used to assess their cognitives and recorded, then statistical analysis was carried out with SPSS 17.0.ＲｅｓｕｌｔｓThe urinary 11DHTXB2 level of the abnormal MMSE group was apparently higher than that of the normal MMSE group (P＜001). The score of MMSE in the abnormal MMSE group was negatively correlated with the urinary 11DHTXB2 level (P＜001). The urinary 11DHTXB2 level of the abnormal MOCA group was apparently higher than that of the normal MOCA group (P＜001). The score of MOCA in the abnormal MOCA group was negatively correlated with the urinary 11DHTXB2 level (P＜001).ＣｏｎｃｌｕｓｉｏｎｓThe urinary 11DHTXB2 level is correlated with cognitive hypofunction in elderly senior intellectuals with asymptomatic cerebral infarction.

Key words: 11-dehydrothromboxane B2, asymptomatic cerebral infarction, education, cognitive