Abstract:

ＯｂｊｅｃｔｉｖｅTo investegate the independent pharmacologic effects of albumin and furosemide on hypoproteinemic elderly patients with acute lung injury or acute respiratory distress syndrome.ＭｅｔｈｏｄｓForty patients with acute lung injury or acute respiratory distress syndrome aged more than 60 were randomly divided into intervention group, receiving treatment of albumin and furosemide, and control group, receiving treatment of furosemide. The oxygenation index, the level of albumin, net fluid loss were measured.ＲｅｓｕｌｔｓThere were no significant differences in baseline characteristics between two groups. Albumintreated patients had increased oxygenation index (P＜001), increased serum albumin (44 g/L vs 095 g/L at day 3, P＜001) and more net fluid loss (P＜001) throughout the study period. Although the mobidity of albuminfurosemide treated patients was lower, there was no significant difference compared with the control patients. The albuminfurosemide treated patients could live longer than those control patients (P＜005).ＣｏｎｃｌｕｓｉｏｎｓThe combination therapy of albumin and furosemide in hypoproteinemic elderly patients with acute lung injury or acute respiratory distress syndrome could significantly improve oxygenation index, increase negative fluid balance, prolong survival time, with no significant benefit in mortality.