Abstract:

ＯｂｊｅｃｔｉｖｅTo observe the changes of brain natriuretic peptide (BNP) levels after drugeluting stent (DES) implantation and to explore the effects of BNP levels on cardiovascular events in elderly patients with stable coronary artery disease (CAD).ＭｅｔｈｏｄｓBetween 2007 and 2009, we conducted a cohort study involving 88 old patients with stable CAD. All were confirmed by coronary angiography (CAG). The data of clinical characteristics, CAG and percutaneous coronary intervention (PCI) were collected. Baseline samples for BNP measurement (microparticle enzyme immunoassay for BNP) were available in total patients. After DES implantation, 29 old patients with stable CAD underwent the measurement of BNP again. The subjects were divided into two groups according to the baseline level of plasma BNP,such cardiovascular events as death, nonfatal ACS, repeated PCI and rehospitalization were recorded.ＲｅｓｕｌｔｓBNP levels in 29 patients after PCI were significantly decreased（from 23043±4881 to 14933±1749 pg/ml, P=00382）. After 125 months followup, higher baseline BNP levels were associated with significantly increased risk of death, nonfatal ACS, repeated PCI and rehospitalization （P＜001）.ＣｏｎｃｌｕｓｉｏｎｓThis study confirms that removal of fixed stenosis after PCI decreases the plasma level of BNP. Baseline elevated BNP concentrations are predictive of adverse cardiovascular events by 1 year after DES implantation in old patients with stable CAD.