Abstract: Objective  To investigate the value of plasma calcitonin gene-related peptide (CGRP) level for predicting morning blood pressure surge (MBPS) after medication in the elderly patients with primary hypertension.  Methods  A total of 112 elderly hospitalized patients with primary hypertension were included. According to the 24 hours ambulatory blood pressure monitoring (ABPM) data after medication, the patients were divided into non-morning peak group (MBPS＜35 mmHg, 53 cases) and morning peak group (MBPS≥35 mmHg, 59 cases). In addition, 14 elderly patients with normal blood pressure were included as control group. The clinical data were collected, and the level of plasma CGRP were detected and compared among the three groups. The related factors of MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension were analyzed by binary Logistic regression, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of the plasma CGRP level for MBPS≥35 mmHg.  Results  The levels of CGRP, clinic systolic blood pressure (SBP), 24-hour SBP (24hSBP), daytime SBP (dSBP), morning SBP, and morning diastolic blood pressure (DBP) in the morning peak group were significantly higher than those in the control group and the non-morning peak group (P＜0.05). And the prevalence of diabetes in the morning peak group was significantly higher than that in the non-morning peak group (P＜0.05). Binary Logistic regression analysis showed that CGRP, morning SBP, 24hSBP, and dSBP were the independent influencing factors for MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension (P＜0.05). ROC curve analysis showed that the area under the curve of CGRP combined with morning SBP, 24hSBP and dSBP for predicting MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension was 0.8791, and the cut-off value of CGRP was 89.52 pg/mL.  Conclusions  Plasma CGRP combined with morning SBP, 24hSBP and dSBP could predict the occurrence of MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension.

Key words: aged')">

aged, primary hypertension, calcitonin gene-related peptide, morning blood pressure surge