老年人外周血PLR、NLR预测及评估帕金森病的价值

doi:10.3969/j.issn.1003-9198.2023.12.010

Abstract

Abstract: Objective To explore the predictive and evaluative value of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) in the elderly patients with Parkinson's disease (PD). Methods Ninety-eight elderly patients with PD hospitalized in the Department of Neurology of Jiangsu Shengze Hospital from 2020 to 2022 were enrolled as PD group. Another 98 elderly who were outpatients or received physical examinations were enrolled as control group. The baseline clinical data were collected. According to the results of Hoehn-Yahr stage, the PD patients were divided into early-stage group (grade 1-2, n=35) and mid- to late-stage group (grade 3-5, n=63). The correlations between various indicators were analyzed by Spearman correlation coefficient. The risk factors for the occurrence and progression of PD were analyzed by multivariate Logistic regression analysis. The receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of PLR, NLR, and the combination of two indicators for the onset of PD. Results There were significant differences in the levels of D-dimer, lymphocytes, neutrophils, PLR and NLR between PD group and control group (P<0.05). Multivariate Logistic regression analysis showed that PLR (OR=1.012) and NLR (OR=1.695) were the independent influencing factors for the occurrence of PD in the elderly. Spearman correlation analysis showed that PLR was positively correlated with the course of disease and Hoehn-Yahr stage in the elderly patients with PD (r=0.225, P=0.026; r=0.316, P=0.002). ROC curve analysis showed that the area under curve (AUC) of NLR and PLR predicting the occurrence of PD was 0.688 and 0.703, respectively. The AUC of the combination of the two indicators was 0.721. There were significant differences in the course of disease and PLR between the early-stage group and mid- to late-stage group (P<0.01). The course of disease (OR=1.250) and PLR (OR=1.010) were the independent influencing factors for the progression of PD. Conclusions NLR and PLR are the independent influencing factors for the occurrence of PD in the elderly. The combination of the two indicators can predict the occurrence of PD. Meanwhile, PLR also affects the severity of PD in the elderly.

Key words: platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, Parkinson's disease, severity

CLC Number:

R 742.5

YANG Jing, ZHANG Jia-sheng, YANG Gui-ying. Predictive and evaluative value of peripheral blood PLR and NLR in elderly patients with Parkinson's disease[J]. Practical Geriatrics, 2023, 37(12): 1228-1232.

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Predictive and evaluative value of peripheral blood PLR and NLR in elderly patients with Parkinson's disease

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