胫骨高位截骨术联合富血小板血浆治疗老年内侧间室骨关节炎的早期价值研究

doi:10.3969/j.issn.1003-9198.2026.04.014

摘要/Abstract

摘要： 目的探讨胫骨高位截骨术(high tibial osteotomy,HTO)联合富血小板血浆(platelet-rich plasma,PRP)治疗老年内侧间室骨关节炎的疗效。方法采用双盲、随机对照试验,通过计算机生成的随机表将50例参与者随机分为A组(HTO+关节腔内PRP注射)和B组(HTO+关节腔内生理盐水注射)。PRP于术前抽取自体血制备,并于术中及术后第14 d各注射1次。于术后3个月进行随访,随访时记录西大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster Universities Osteoarthritis Index,WOMAC)评分和VAS评分,比较2组差异。结果 3个月后,2组WOMAC以及VAS评分均较治疗前降低,且A组WOMAC及VAS评分显著低于B组,差异有统计学意义(均P＜0.05)。结论治疗老年人膝关节疼痛,HTO联合PRP可能是一种更合理的选择,可改善膝关节功能。

关键词: 老年人, 胫骨高位截骨术, 富血小板血浆, 膝关节内侧间室骨关节炎

Abstract: Objective To evaluate the efficacy of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) in the treatment of medial compartment osteoarthritis in the elderly patients. Methods In this double-blind, randomized controlled trial, 50 patients were randomly assigned into group A (HTO + intra-articular PRP injection) and group B (HTO + intra-articular saline injection) via computer-generated randomization. PRP was prepared preoperatively from autologous blood and administered during surgery and 14 d after operation. Follow-ups were conducted for 3 months, with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analogue Scale (VAS) scores recorded at each visit. The differences were compared between the two groups. Results 3 months after operation, the total WOMAC scores and VAS scores were significantly lower in both groups compared with those before operation, especially in group A(P＜0.05). Conclusions HTO combined with PRP may represent a more rational treatment option for alleviating knee pain and improving knee joint function of medial compartment osteoarthritis in elderly patients.

Key words: aged, high tibial osteotomy, platelet-rich plasma, medial compartment osteoarthritis

中图分类号:

R 684

戚荣富, 谢曈, 周杰, 周利武, 尹海建. 胫骨高位截骨术联合富血小板血浆治疗老年内侧间室骨关节炎的早期价值研究[J]. 实用老年医学, 2026, 40(4): 400-405.

QI Rongfu, XIE Tong, ZHOU Jie, ZHOU Liwu, YIN Haijian. Early application value of high tibial osteotomy combined with platelet-rich plasma in the treatment of elderly patients with medial compartment osteoarthritis[J]. Practical Geriatrics, 2026, 40(4): 400-405.

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