ＯｂｊｅｃｔｉｖｅTo evaluate the clinical value of bipositive airway pressure (BiPAP)noninvasive ventilation in treating severe pneumonia complicated with left heart failure in elderly patients and the influence on plasma brain natriuretic peptide(BNP).ＭｅｔｈｏｄｓThirtysix elderly patients with severe pneumonia complicated with left heart failure were randomly divided into treatment group and control group.The treatment group (18 cases) was treated by BiPAP combined with routine therapy,and the control group (18 cases) treated by routine therapy including antiinfection,antitussive and expectorant, antiasthma,vasodilator,nitrates,cedilanid,diuretics combined with oxygen before and 72 hours after treatment. Systolic blood pressure,heart rate,respiratory rate,bloodgas analysis(pH,PaO2,PaCO2,SaO2) and the clinical signs were observed 72 hours after treatment.The concentrations of plasma BNP was also measured before and 72 hours after treatment.ＲｅｓｕｌｔｓThe clinical symptoms and signs were significantly improved,SaO2 and PaO2 significantly elevated,RR,HR significantly reduced(P＜005) in treatment group than those in control group.The plasma level of BNP were significantly decreased after treatment in both groups,especially in the treatment group(P＜001).ＣｏｎｃｌｕｓｉｏｎｓBiPAP could improve hypoxemia and cardiac function and reduce the plasma BNP concentration in elderly patients with severe pneumonia complicated with heart failure.
