Abstract:

ＯｂｊｅｃｔｉｖｅTo investigate the effect of noninvasive positivepressure respiration on serum Nterminal probrain natriuretic peptide (NTproBNP) in elderly patients with chronic heart failure(CHF).ＭｅｔｈｏｄｓOne hundred and twenty patients with CHF were randomly divided into two groups. The control group received only routine treatment, the experimental group received routine treatment, and was also treated with bilevel positive airway pressure ventilation ( BiPAP). The levels of NTproBNP were measured before and 12 h, 24 h, 72 h, 7 d and 14 d after the treatment in two groups. The symptoms and physical signs of heart failure were evaluated.ＲｅｓｕｌｔｓAfter 24hour treatment, the levels of NTproBNP in the experimental group descended significantly compared with that of control group. Additional improvement was higher in the experimental group compared with the control group. There was significant difference in two groups ( P＜001). ＣｏｎｃｌｕｓｉｏｎｓApplication of BiPAP respiratory ventilation could decrease the plasma NTproBNP level in elderly patients with CHF. It is an effective and safe method in treating CHF.

Key words: noninvasive positivepressure respiration, chronic heart failure, Nterminal probrain natriuretic peptide