Abstract:

ＯｂｊｅｃｔｉｖｅTo observe the effects of memantine on serum SOD and NSE in patients with Alzheimers disease(AD).ＭｅｔｈｏｄｓSixtyseven elderly patients with AD were randomly divided into memantine treatment group and routine treatment group. Thirtynine healthy subjects were chosen as normal group. The serum concentration of SOD was measured by chemical colorimetry. The serum concentration of NSE was measured by enzymelinked immunosorbent assay (ELISA).ＲｅｓｕｌｔｓAfter 6 months of treatment, the level of serum SOD and the score of MMSE in memantine treatment group were higher than those in normal treatment group; the level of NSE in memantine treatment group was lower than that in normal treatment group. After 6 months of treatment, the serum level of SOD in memantine treatment group increased, and the serum level of NSE in memantine treatment group decreased; the score of MMSE in memantine treatment group was higher than that before treatment.ＣｏｎｃｌｕｓｉｏｎｓThe therapy of memantine could reduce oxidative stress and get better efficacy in treating AD.